Yes this is possible, but you may encounter a problem encrypting files/folders larger than 4GB. This is due to the limitations imposed by the FAT or FAT32 file formatting system that is used by most manufacturers of USB flash drives. There is no technical solution to resolve this hardware limitation. However, you can reformat flash drives in most cases to use the exFAT file formatting system, which in reality does not have a file size limit and reads and writes files on both Windows and Mac operating systems.
Filesystem formatting options include NTFS and exFAT. We do not recommend NTFS, because Mac cannot natively write files to a USB with that formatting system. exFAT reads and writes files on both Windows and Mac platforms.